Feriel Tiar1, Teodora-Adriana Perles-Barbacaru1, Michelle El-atifi1, Didier Wion1, Laurent Pelletier1, Hana Lahrech1, Francois Berger1
1INSERM U 836, Grenoble Institute of Neurosciences, La Tronche, France
A new orthotopic mouse model derived from human glioblastoma spheres was recently developed. Tumor growth kinetics and response to temozolomide treatment was assessed by MRI. Similar to clinically encountered glioblastomas, this model develops over several months, has an infiltrating growth pattern, mimics their cellular heterogeneity and presents a temozolomide failure. It will therefore be useful for the preclinical evaluation of new treatment strategies.