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Abstract #3446

Rapid ex vivo Imaging of PAIII Prostate to Bone Tumor with SWIFT-MRI

Ihor Luhach1, Djaudat Idiyatullin2, Conor Lynch1, Curtis Andrew Corum, Gary V. Martinez1, Michael Garwood, Robert J. Gillies3

1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States; 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 3H. Lee Moffitt Cancer Center, Tampa, FL, United States

In U.S. almost 30,000 men die from prostate cancer every year. Up to 90% of them develop bone metastasis. Early detection of metastases can be beneficial for treatment and long term survival.Sweep Imaging with Fourier Transform or SWIFT is a new MRI method capable of detecting signals with a broad range of T2 times including extremely short ones that are present in bone. In this work control and PAIII tumor bearing mice tibia were imaged with SWIFT, traditional CT, gradient echo and spin echo. SWIFT was capable to detect tumor and tumor related osteogenesis in the same image.