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Abstract #3447

Relationships Between Diffusion Weighted Signal Intensity, ADC and Water/fat Content of Malignant Bone Marrow

Ashik Amlani1, Subhadip Ghosh-Ray1, Katherine van Ree1, Andreas Makris2, Shirley D'Sa2, Peter Ostler2, Nicola Anyamene2, Anwar R. Padhani1

1Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, London, Middlesex, United Kingdom; 2Mount Vernon Cancer Centre, London, United Kingdom

There are stepwise increases in tissue-normalised SI, ADC values and water:fat ratio when sequentially comparing YBM to RBM and malignant bone marrow disease. The polynomial relationships between both DW-SI and water:fat ratio with ADC values are independent of tumour type allowing an opportunity to set a generally applicable upper ADC limit (threshold) for untreated/relapsed disease.