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Abstract #3459

A Longitudinal Study on the Relationship Between BMD and Bone Marrow Perfusion of Proximal Femur Based on DCE-MRI

Heather T. Ma1, James F. Griffith2, Haiyan Lv1, Alvin FW Li2, David K.W. Yeung2, Anthony Kwok2, Ping-Chung Leung2

1Department of Electronic and Information Engineering, Harbin Insitute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; 2Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

This study investigated relationship between bone marrow perfusion and bone mineral density (BMD) at proximal femur over 4 years. Dynamic contrast enhanced MRI data was extracted pixel-by-pixel and classified into 3 patterns to indicate the perfusion function. For the subjects with good bone marrow perfusion, their BMD would keep stable after 4 years, while for those with bad perfusion, their BMD consistently decreased over 4 years. The results indicated that the perfusion function could have a long term effect on BMD and a good perfusion function would help to keep the bone health.