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Abstract #3460

Addressing Overlapping Water-Fat Peaks and Water-Fat Chemical Shift Displacement Effects in Single-Voxel MRS of Bone Marrow

Dimitrios C. Karampinos1, 2, Gerd Melkus1, Thomas Baum2, Jan S. Bauer2, Ernst J. Rummeny2, Roland Krug1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany

There is a growing interest in understanding the linkage between bone mineral density and bone marrow adiposity. Single voxel MR spectroscopy (MRS) has been previously used to measure fat content in bone marrow. However, single-voxel MRS of bone marrow is characterized by overlapping water-fat peaks due to broad linewidths and is sensitive to chemical shift displacement effects due to finite RF pulse bandwidths. We describe a methodology addressing the above issues using an acquisition with two center frequencies and MRS fitting routines taking into account an a priori known model for the chemical structure of triglycerides.