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Abstract #3461

Fat Fraction and Bone Mineral Density in the Proximal Femur: A Localized Assessment of Their Relationship in Fragility Fractures

Julio Carballido-Gamio1, Dimitrios C. Karampinos1, 2, Andrew Lai1, Sonia Lee1, Roland Krug1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany

Bone strength is yielded by bone mineral density (BMD) and by bone quality. Studies have suggested that bone fat content can partly explain bone strength independently of BMD, and that bone fat content and BMD are negatively correlated. In this study, we used Magnetic Resonance Imaging (MRI), Quantitative Computed Tomography (QCT), and Computational Anatomy to assess the spatial relationship between fat fraction (FF) and volumetric BMD (vBMD) in the proximal femur of normal postmenopausal women, and women with fragility fractures. FF and vBMD were mostly negatively correlated in both normal women and women with fragility fractures, however there was a trend towards a different spatial pattern of the strength of these relationship.