Abstract #3491

Improved IVIM Image Quantitation of Exercised Lower Back Muscles by Local Principle Component Analysis

Patrick Hiepe¹, Daniel Gllmar², Alexander Gussew³, Reinhard Rzanny², Jrgen R. Reichenbach²

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology I , Jena University Hospital, Jena, Germany; ²Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany; ³Medical Physics Group, Institute of Diagnostic and Interventional Radiology I , Jena University Hospital - Friedrich Schiller University Jena , Jena, Germany

In this contribution the intra-voxel incoherent motion model (IVIM) imaging and local principle component analysis (LPCA) denoising was used to evaluate muscle fatigue by quantifying the load-induced perfusion changes in lower back muscles following exercise. LPCA decomposition was applied to improve image quality. Mapped diffusion coefficients (parameterized via D) and perfusion-related signal losses (parameterized via f) were used for ROI-based analyses. Mean D and f values revealed spatially varying increases post exercise which can thus be used for spatially resolved perfusion quantification as a physiological marker of muscle activity and fatigue during exercise.