Three Dimensional Mapping of Oxidative Capacity in Human Lower Leg Muscles with Compressed Sensing 31P-MRI

Prodromos Parasoglou¹, Li Feng¹, Ding Xia¹, Ricardo Otazo¹, Ravinder R. Regatte¹

The rate of phosphocreatine resynthesis following physical exercise is an accepted index of mitochondrial oxidative metabolism. Several diseases can affect the efficiency of muscles� oxidative metabolism in the mitochondria, which could lead to spatial heterogeneity of the muscles� response to physical exercise. However, very little is known about these spatial gradients of metabolic properties due to the lack of imaging tools with sufficient muscle coverage and temporal resolution to measure oxidative capacity in larger areas of tissue. In this work, we developed and implemented a novel compressed sensing (CS) 3D-31P-MRI technique for imaging PCr resynthesis following exercise.