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Abstract #3493

Three Dimensional Mapping of Oxidative Capacity in Human Lower Leg Muscles with Compressed Sensing 31P-MRI

Prodromos Parasoglou1, Li Feng1, Ding Xia1, Ricardo Otazo1, Ravinder R. Regatte1

1Department of Radiology, New York University Langone Medical Center, New York, NY, United States

The rate of phosphocreatine resynthesis following physical exercise is an accepted index of mitochondrial oxidative metabolism. Several diseases can affect the efficiency of muscles´┐Ż oxidative metabolism in the mitochondria, which could lead to spatial heterogeneity of the muscles´┐Ż response to physical exercise. However, very little is known about these spatial gradients of metabolic properties due to the lack of imaging tools with sufficient muscle coverage and temporal resolution to measure oxidative capacity in larger areas of tissue. In this work, we developed and implemented a novel compressed sensing (CS) 3D-31P-MRI technique for imaging PCr resynthesis following exercise.