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Abstract #3524

Assessment of Skeletal Muscle Oxygen Kinetics Using Quantitative BOLD (QBOLD)

Xiang He1, Serter Gumus1, Jung-Hwan Kim1, Ted Huppert1, Bret Goodpaster2, Dmitriy A. Yablonskiy3, Kyongtae Ty Bae1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 22Department of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, United States; 3Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, United States

In this study, calf muscle oxygen kinetics was investigated utilizing an MR single-voxel qBOLD (quantitative BOLD) approach during muscle exercise. Changes in muscle hemodynamics such as oxygen extraction fraction (OEF) and deoxygenated blood volume (DBV) were measured during and after isometric or dynamic knee dorsiflexion. This study demonstrated that while post-exercise hyperemia was evident, muscle functional MRI (mfMRI) response during static or dynamic exercise was dominated by changes in deoxygenated blood volume and deoxy-hemoglobin concentration.