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Abstract #3525

Preliminary MR DTI Study of Age-Related Regeneration Process of Skeletal Muscle with Ischemia Injury

Ke Jiang1, Xiaotian Wang1, 2, Hulong Lei1, Wei Yang1, Yin Wu1

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; 2Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, Liaoning, China

DTI is a powerful tool to investigate muscle structures. Most DTI studies of probing ischemic muscle were performed on adult species, results of which may not apply on other age populations. In this study, we aim to investigate age-related regeneration process of ischemic muscle. 10 young and old SD rats were longitudinally studied using DTI before and after ischemia induction. Results showed that the young group was more sensitive to ischemia and recovered more rapidly than the old group. This study demonstrates the age-related discrepancy of muscle regeneration process, and may provide supplemental information for understanding of muscle repair evolution.