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Abstract #3546

Alternative Methods for Transforming T2 Anisotropy of MRI Into Collagen Architecture of Articular Cartilage the Effect on Knee Joint Mechanics Data from the Osteoarthritis Initiative (OAI)

Lasse P. Rsnen1, 2, Mika E. Mononen1, Miika T. Nieminen3, 4, Eveliina Lammentausta3, Jukka S. Jurvelin1, Rami K. Korhonen1

1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; 2Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland; 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 4Department of Radiology, University of Oulu, Oulu, Finland

The collagen architecture modulates the stresses and strains in a knee joint. Here, two alternative methods for determining the depth-dependent collagen architecture from T2 profiles of clinical MRI were compared. Collagen architectures were implemented into a computational model of a knee joint and the differences in the mechanical response of cartilage were evaluated. The stresses varied up to 49% between the two models. These results emphasize the importance of the collagen architecture, and the role of the the depth-wise T2 analysis method, for evaluation of cartilage stresses and strains in a knee joint.