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Abstract #3595

Impaired Small-World Efficiency in Structural Networks in Pediatric Bipolar Disorder

Minjie Wu1, Alexander Kmicikewycz1, Shaolin Yang1, Lisa Lu1, 2, Donatello Arienzo1, Mani Pavuluri1

1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychology, Roosevelt University , Chicago, IL, United States

In the current study, graph theoretic analyses was applied to diffusion weighted data to explore the topological efficiency of structural networks in pediatric bipolar disorder (PBD). Significantly decreased small-worldness in PBD was observed, which may reflect decreased efficiency in information transfer, and may contribute to the affective and cognitive dysfunction in PBD.