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Abstract #3596

Increased Glutathione Levels in Chronic and Recent Onset Schizophrenic Patients

Susanne Bonekamp1, Richard Anthony Edward Edden1, Nicolaas A. J. Puts2, Jennifer M. Coughlin3, He Zhu, 24, Mark Varvaris5, Nicola Cascella6, Akira Sawa3, Peter B. Barker1

1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2Radiology, JHU, Baltimore, MD, United States; 3Psychiatry and Behavioral Sciences, JHU, Baltimore, MD, United States; 4Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 5Neuro Cognitive Neurology, JHU, Baltimore, MD, United States; 6Neuropsychiatry, Sheppard Enoch Pratt Hospital, Towson, MD, United States

It has been suggested that oxidative stress plays a role in the pathogenesis of Schizophrenia. This study provides support for the hypothesis that in vivo levels of gluthathione, the major antioxidant in the brain, are altered in the anterior cingulate cortex and dorsolateral prefrontal cortex of patients with Schizophrenia. Further studies are still needed to determine underlying mechanisms, including the effects of treatment, and to investigate the relationship between GSH levels, other markers of oxidative stress, and severity of both positive and negative symptoms.