Meeting Banner
Abstract #3652

White Matter Connectivity and Network Analysis in Polymicrogyria Using an Individual's Primary Gyral Pattern

Kiho Im1, Michael J. Paldino1, Olaf Sporns2, Patricia Ellen Grant3

1Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; 2Indiana University, Bloomington, IN, United States; 3Boston Children's Hospital, Boston, MA, United States

The major contribution of the current study is to provide the first detailed findings and interpretations on abnormal cortical network topology in malformations of cortical development, in particular polymicrogyria, related to extent of abnormal gyral folding. We propose a novel structural connectivity network analysis based on an individuals primary gyral pattern and topology, which is biologically more meaningful and able to better capture and describe individual brain network.