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Abstract #3653

Left Hippocampal Volume Reduction Is Strongly Coupled with Structural and Functional Connectivity in Patients with Left Mesial Temporal Lobe Epilepsy

Y.C. Shih1, 2, H.H. Liu3, C.E. J. Tseng2, Wen-Yih Isaac Tseng2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan Univerity College of Medicine, Taipei, Taiwan, Taiwan; 3Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, Taiwan

The hippocampal sclerosis (HS) is the general abnormality observed in patients with mesial temporal lobe epilepsy (MTLE). We have confirmed the altered structural connectivity related to HS or hippocampal atrophy in left MTLE, however, the functional connectivity between these two regions is still unclear. We hypothesized that there were relationships between structural and functional connectivity caused by HS. The present study reveals the relationships among the integrity of the inferior CB, the volume of hippocampal gray matter and the strength of functional connectivity in the lesion side of patients with HS.