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Abstract #3676

Multi-Parameter MRI Assessment of Glioma Response to Radiotherapy

Xiaohua Hong1, 2, Silun Wang1, Jinyuan Zhou1

1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Several MRI modalities were applied to rat U87MG tumors that were treated with radiotherapy (40 Gy). It was found that the APT signal in the radiated tumor significantly decreased from day 3 post-treatment and the ADC signal significantly increased from day 6 post-treatment. Our results show that both APT and ADC were biomarkers that can early assess glioma response to radiotherapy.