Abstract #3682

MRI of Neuronal Recovery After Methamphetamine Treatment of Traumatic Brain Injure in Rats

Guangliang Ding¹, Michael Chopp¹,², David J. Poulsen³, Lian Li¹, Changsheng Qu⁴, Qingjiang Li¹, Siamak P. Nejad-Davarani¹, John Budaj¹,⁵, Hongtao Wu⁴, Asim Mahmood⁴, Quan Jiang¹

¹Neurology, Henry Ford Hospital, Detroit, MI, United States; ²Physics, Oakland University, Rochester, MI, United States; ³Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, United States; ⁴Neurosurgery, Henry Ford Hospital, Detroit, MI, United States; ⁵Biomedical Engineering, Oakland University, Rochester, MI, United States

Traumatic brain injury (TBI) is an important public health problem in Western countries. There is an urgent need to develop a novel approach for the treatment of TBI. With a CCI model of TBI in young Wistar rats, methamphetamine treatment of TBI significantly improved white matter reorganization at 5 to 6 weeks after TBI, compared with saline treatment, based on the MRI FA measurements. And significant correlation was detected between the FA and histological BLFB measurements. It suggested that the the improved white matter may contribute to the functional recovery after TBI in rat.