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Abstract #3683

Longitudinal Anatomical and Diffusion MRI Evaluation in Rabbit External Capsules and Hippocampi After Cerebral Hemisphere Radiation Exposure

Chao-Yu Shen1, 2, Zhen-Hui Li1, Tao-Tao Chen1, Yeu-Sheng Tyan1, 2, Jun-Cheng Weng1, 2

1School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan; 2Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

In the study, we used a linear accelerator as the source of radiation to establish an adult rabbit model for single-dose cerebral hemisphere exposure radiation-induced brain injury, and afterward, it longitudinally evaluated the changes in various brain compartments on a 1.5T clinical MR scanner by using T2 weighted imaging (T2WI) and diffusion tensor imaging (DTI) indices: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) mapping. It is hoped that this experimental model can be used to evaluate the neuro-toxic adverse effects of irradiation treatment.