Abstract #3685

DTI Study of Corpus Callosum Integrity in Adult Macaques with Neonatal Hippocampal Lesion

Yuguang Meng¹, Longchuan Li², Xiaoping P. Hu², Jocelyne Bachevalier³, Christa Payne³, Xiaodong Zhang¹,⁴

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; ²Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; ³Yerkes National Primate Research Center and Department of Psychology, Emory University, Atlanta, GA, United States; ⁴Division of Neuropharmacology and Neurologic Disease, Emory University, Atlanta, GA, United States

An earlier study on the impact of hippocampal lesions on the integrity of the corpus callosum (CC) and its inter-hemispheric connectivity indicated a reduction in the surface area of the posterior CC. To assess whether the same CC changes will follow the hippocampal lesions occurred in early life, the present study measured CC integrity in adult monkeys with neonatal hippocampal lesions. Mean diffusivity data showed alterations of posterior CC segment and transcallosal fibers from the posterior parietal and retrosplenial cortex, the damage of which would impair visuospatial processing functions due to Neo-H lesions.