Yi-Ling Wu1,
Sheng-Min Huang1, Shin-Lei Peng1, Yi-Chun Wu2,
Tao-Chieh Yang3, Jee-Ching Hsu4, Ming-Long Wu5,
Fu-Nien Wang1
1Department
of Biomedical Engineering & Environmental Sciences, National Tsing Hua
University, Hsinchu, Taiwan; 2Animal Molecular Center, Chang Gung
Memorial Hospital, Taoyuan, Taiwan; 3Department of Neurosurgy,
Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of
Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department
of Computer Science and Information Engineering, National Cheng Kung
University, Tainan, Taiwan
In this study we investigated the resting state (RS) networks of attention deficit and hyperactive disorder (ADHD) using spontaneously hypertensive rats (SHR). RS network of SHR was found to be more active than normal rat in primary somatosensory (S1) and insular cortex region. The hyperactivity in S1 is speculated to be the possible reason of attention deficit since rats are sensitive to external changes. Though the detail connections of RS network and physiological functions should be further examined, our works suggest the feasibility to evaluate RS network differences by rat model. More case studies of ADHD could be conducted via rat model.
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