Abstract #3691

Alterations of Temporal and Prefrontal White Matter in Adult Macaques with Neonatal Hippocampal Lesion

Yuguang Meng¹, Longchuan Li², Xiaoping P. Hu², Jocelyne Bachevalier³, Christa Payne³, Xiaodong Zhang¹,⁴

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; ²Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; ³Yerkes National Primate Research Center and Department of Psychology, Emory University, Atlanta, GA, United States; ⁴Division of Neuropharmacology and Neurologic Disease, Emory University, Atlanta, GA, United States

A recent diffusion tensor imaging (DTI) study demonstrated that excitotoxic hippocampal lesions in adult macaques alter white matter tracts of the temporal and frontal lobes. In the present study, DTI was used to examine whether similar changes will also be found in adult macaque monkeys with similar selective hippocampal lesions done in infancy. Significant diffusivity alterations were found in the white matter of the temporal stem and ventromedial prefrontal cortex which is involved in memory consolidation and working memory retrieval.