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Abstract #3865

Labeling of Macrophages with Novel Gadolinium Oxide Nanoparticles for in vivo Imaging of Inflammation

Gary R. Stinnett1, Minjung Cho2, Huigang Zhu2, Pedersen E. Steen1, Christeen Beeton1, Vicki L. Colvin2, Robia G. Pautler1

1Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, United States; 2Chemistry, Rice, Houston, TX, United States

We have developed novel gadolinium oxide contrast agents with an R1 three times higher than Magnevist in a 9.4 T MRI. These agents were used to label macrophages resulting in labeled cells significantly brighter than non-labeled cells.