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Abstract #3873

Evaluation of ParaCEST Detection Threshold on Human Stem Cells Under Physiological Constraints

Wen Ling1, Francesca Nicholls1, 2, Silvio Aime3, Daniela Delli Castelli3, Michel Modo1

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2dept of Neuroscience, King's College London, London, United Kingdom; 3Dept of Chemistry, University of Torino, Torino, Italy

Optimal detection conditions were established for paraCEST to detect different cell populations in vitro. The scanning conditions were further verified by the fact that human neural stem cells can withstand up to 5 hrs without significant effects on their viability. The detection threshold was then evaluated in terms of concentration and voxel size.