Investigation of the CEST Effect in Prostate Metabolites

Meer Basharat¹, Maysam Jafar¹, Nandita M. deSouza¹, Geoffrey Payne¹

Experiments were performed at 11.7T for the first time on solutions of spermine and citrate, to discover whether these two major prostate secretions demonstrate a CEST effect at expected pH and concentration conditions. There was a 42% CEST effect for 10mM spermine at pH 6.0 at 310K, but no considerable CEST effect for 100mM citrate at pH1.8 also at 310K. SpermineCEST was increased with acidity, but decreased with higher citrate and temperature levels. This latter behaviour is not expected, so spermineCEST will be explored with other metabolite concentrations and by performing CEST on the related chemicals putrescine and spermidine.