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Abstract #3887

D-Glucuronic Acid Coated DyEuO3 and HoEuO3 Nanoparticles for Magnetic Resonance Imaging (MRI) and Fluorescence Imaging (FI)

Wenlong Xu1, Krishna Kattel1, Md. Wasi Ahmad1, Badrul Alam Bony1, Tirusew Tegafaw1, Woo Choul Heo1, Cho Rong Kim1, Yongmin Chang2, Gang Ho Lee1

1Department of Chemistry, Kyungpook National University, Buk-gu, Daegu, Korea; 2Department of molecular medicine, Kyungpook National University, Buk-gu, Daegu, Korea

A dual imaging now emerges as a new and advanced imaging technique in clinical applications. The single-phase mixed DyEuO3 and HoEuO3 nanoparticles are potential candidates for dual imaging experiment. It is expected that it will play a key role to diagnose diseases by replacing conventional single-imaging techniques. For example for MRI-FI dual imaging, the fluorescence imaging can be used to locate a disease and then MRI can be used to obtain high resolution MR images around the disease. We developed a facile synthesis of ultra-small D-Glucuronic acid coated Eu3+ doped Dysprosium oxide nanoparticles and Holmium oxide nanoparticles. The capability of nanoparticles as T2 MRI contrast agent was proved in vivo through T2 MR images of a rat. The fluorescent images were observed in vitro by taking DU145 and NCTC1469 cells. The nanoparticles exhibited no appreciable cytotoxicity up to 100 &[mu]M concentrations and in vivo MR experiment showed the negative contrast enhancement on mouse liver and kidneys after the injection of nanocolloid. Hence, it can be used as a fluorescence imaging agent as well as a T1 MRI contrast agent.