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Abstract #3900

Magnetic Resonance Imaging(MRI) and X-Ray Computed Tomography(CT) Dual Functionality of Gadolinium Iodate Dihydrate Nanomaterials

Cho Rong Kim1, Eun Jung Lee1, Woo Choul Heo2, Yongmin Chang3, Gang Ho Lee1

1Chemistry, Kyungpook national university, Daegu, Korea; 2Chemistry, Kyungpook National University, Daegu, Korea; 3School of medicine, Kyungpook National University, Daegu, Korea

We synthesized D-glucuronic acid coated Gd(IO3) 3.2H2O nanomaterials and for the first time investigated their magnetic properties, water proton relaxivities, and X-ray phantom images. D-glucuronic acid coated Gd(IO3) 3.2H2O nanomaterials were paramagnetic, with very large longitudinal (r1) and transverse (r2) water proton relaxivities of 52.3 and 63.4 s-1mM-1, respectively, both of which were larger than those of commercial Gd-chelates. Hydrated water molecules seem to serve as a reservoir for strong MR signals. The stronger contrast enhancements in X-ray phantom images than those of commercial molecular iodine CT contrast agents were also observed. These results revealed that D-glucuronic acid coated Gd(IO3) 3.2H2O nanomaterials should be a potential candidate for a MRI-CT dual contrast agent.