Abstract #3901

MRI and Fluorescence Imaging with Upconverting Nanoparticles: a New Multimodal Approach for Lung Targeting

Hugo Groult¹,², Andrea Bianchi³, Moreno Zamai⁴, Jesus Ruiz-Cabello¹, Yannick Crmillieux³, Fernando Herranz-Rabanal¹

¹Advanced imaging unit, CNIC (centro nacional de investigaciones cardiovasculares), Madrid, Spain; ²CIBERES (Centro de Investigacon biomedica en red Enfermedades Respitorias), Bunyola,, Mallorca, Spain; ³Cardio-thoracic Center of Bordeaux, University of Bordeaux Segalen, Bordeaux, Aquitaine, France; ⁴Microscopy and Dynamic imaging Unit, CNIC (centro nacional de investigaciones cardiovasculares), Madrid, Spain

One of the most attractive approaches in molecular imaging is the combination of fluorescence with MRI, providing high sensitivity and resolution together with structural and functional data. We present here the physicochemical characterization and the in vitro and in vivo multimodal study (MR and fluorescence imaging) of a new class of nanoparticles based on UpConverting NanoPhosphors albumin-coated. These nanoparticles present the unique feature of converting low energy near-infrared (NIR) light into higher visible light and/or NIR emission, which allow to overcome all the typical problems of fluorescent probes. At the same time they can be combined to MR imaging modality.