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Abstract #3902

Magnetic Resonance-Fluorescent Dual Imaging of Fluorescein Coated Gd2O3 Nanoparticles

Tirusew Tegafaw Mengesha1, Krishna kattel1, Wenlong Xu1, Badrul Alam Bony1, Woo Choul Heo1, Kim Cho Rong1, Md. Wasi Ahmad1, Yong Min Chang2, Gang Ho Lee1

1Departement of Chemistry, Kyungpook National University, Daegu, Korea; 2Departement of molecular medicine, Kyungpook National University, Daegu, Korea

MRI is a very useful technique in diagnosing diseases because of its high spatial resolution and good sensitivity. Detection of diseases can be further improved by using MRI contrast agents through contrast enhancement. Fluorescein coated gadolinium oxide nanoparticles are promising candidates as either T1 MRI-CL or MRI-FI dual agents because gadolinium oxide nanoparticles show a longitudinal relaxivity (r1) which is much larger than those of Gd (III) -chelates while dyes generally provide a very strong fluorescent intensity. The enhanced r1 of gadolinium oxide nanoparticles with respect to those of Gd (III) - chelates is due to a high density of probing Gd (III) ions in nanoparticles.