Abstract #3902

Magnetic Resonance-Fluorescent Dual Imaging of Fluorescein Coated Gd2O3 Nanoparticles

Tirusew Tegafaw Mengesha¹, Krishna kattel¹, Wenlong Xu¹, Badrul Alam Bony¹, Woo Choul Heo¹, Kim Cho Rong¹, Md. Wasi Ahmad¹, Yong Min Chang², Gang Ho Lee¹

¹Departement of Chemistry, Kyungpook National University, Daegu, Korea; ²Departement of molecular medicine, Kyungpook National University, Daegu, Korea

MRI is a very useful technique in diagnosing diseases because of its high spatial resolution and good sensitivity. Detection of diseases can be further improved by using MRI contrast agents through contrast enhancement. Fluorescein coated gadolinium oxide nanoparticles are promising candidates as either T1 MRI-CL or MRI-FI dual agents because gadolinium oxide nanoparticles show a longitudinal relaxivity (r1) which is much larger than those of Gd (III) -chelates while dyes generally provide a very strong fluorescent intensity. The enhanced r1 of gadolinium oxide nanoparticles with respect to those of Gd (III) - chelates is due to a high density of probing Gd (III) ions in nanoparticles.