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Abstract #3903

pH-Triggered 19F MRI for Lung Cancer Cell A549

Shizhen Chen1, Yuqi Yang1, Qi Wang1, Haidong Li1, Xin Zhou1

1Wuhan Center for Magnetic Resonance,Wuhan Institute of Physics and Mathematics,CAS, Wuhan, Hubei, China

We developed a novel nanosized and pH-trigged biosensor, which encapsulates high-sensitive 19F MRI contrast agent in gold nanoparticles (AuNPs)-capped mesoporous silica nanoparticles (MSNs) platform,and this biosensor is capable to specifically target to lung cancer cell (A549) for intracellular MRI.