Abstract #3917

Optimized Sampling of Metabolically Labeled [2-13C]Lactate Following Injection of Hyperpolarized [2-13C]Pyruvate

Ralph Hurd¹, Sonal Josan²,³, Jae Mo Park²,⁴, Yi Fen Yen², Dirk Mayer²,³, Daniel Spielman²,⁴

¹GE Healthcare, Menlo Park, CA, United States; ²Radiology, Stanford University, Stanford, CA, United States; ³Neuroscience Program, SRI International, Menlo Park, CA, United States; ⁴Electrical Engineering, Stanford University, Stanford, CA, United States

With the increased use of hyperpolarized [2-13C]pyruvate in metabolic spectroscopy and imaging, there is an emerging need for optimized sampling of the metabolically labeled [2-13C]lactate. Toward that goal, the T1 of [1-13C]lactate was measured in vivo and used to calculate optimum flip angles for time-resolved spectroscopic data collection. An equimolar mixture of 40 mM [1-13C]pyruvate and 40 mM [2-13C]pyruvate was used to compare the apparent in vivo T1s and to optimize the time-resolved sampling of [2-13C]lactate with [1-13C]lactate.