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Abstract #3918

Evaluation of Renal Metabolic Response to Partial Ureteral Obstruction with Hyperpolarized 13C MRI

David J. Niles1, Jeremy W. Gordon2, Gengwen Huang3, Kevin M. Johnson1, Arjang Djamali4, Sean B. Fain1, 5

1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 3Surgery, University of Wisconsin, Madison, WI, United States; 4Medicine, University of Wisconsin, Madison, WI, United States; 5Radiology, University of Wisconsin, Madison, WI, United States


Congenital obstructive nephropathy is the most common cause of end-stage renal disease in children, and there is a need to improve tools for early diagnosis. In this study we used hyperpolarized 13C MRI to longitudinally and non-invasively assess the hemodynamic and metabolic changes in the kidney following partial unilateral ureteral obstruction. We observed reduced blood flow to the obstructed kidney and a preferential shift toward glycolysis in both kidneys. Our results may contribute to the understanding of the pathogenesis of obstructive nephropathy and to the development of improved approaches for clinical assessment.