Albert P. Chen1, Charles H. Cunningham2, 3
1GE Healthcare, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3Dept. of Medical Biophysics , University of Toronto, Toronto, ON, Canada
Preparation of hyperpolarized [1-13C]lactate in solution was demonstrated in this study using neat [1-13C]lactic acid as the DNP sample. Hyperpolarized [1-13C]lactate was also compared to [1-13C]pyruvate for in vivo investigation of cardiac PDH flux at the same dose in the same subjects. Hyperpolarized [1-13C]lactate may provide non-invasively assessment of cardiac PDH flux with minimal perturbation of the enzymes involved in this metabolic pathway.