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Abstract #3929

Towards Real-Time Metabolic and Molecular Imaging of Cancer by Three Different Modalities of Hyperpolarization

Niki Zacharias1, Maja Cassidy2, Mark Lingwood3, Napapon Sailasuta4, Nicholas Whiting1, Jingzhe Hu5, 6, Song-I Han3, Brian Ross4, Charles Marcus2, 7, Pratip Bhattacharya8

1Experimental Diagnostic Imaging, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States; 2Harvard University, Cambridge, MA, United States; 3Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States; 4Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, CA, United States; 5Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; 6Bioengineering Department, Rice University, Houston , TX, United States; 7University of Copenhagen, Copenhagen, Denmark; 8Experimental Diagnostic Imaging, University of Texas, Houston, TX, United States

Hyperpolarized magnetic resonance is a non-toxic, non-radioactive method for assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for over 10,000-fold signal enhancement relative to conventional magnetic resonance imaging (MRI) or spectroscopy (MRS). My laboratory has worked on three different modalities of hyperpolarization, both on technique development as well as advancing novel in vivo applications. The research described here is focused on the different in vivo applications of Parahydrogen Induced Polarization (PHIP) (and subsequent transfer to 13C), continuous flow Dynamic Nuclear Polarization (DNP) of water (1H), and long lived DNP hyperpolarized signal of Silicon nanoparticles (29Si) as molecular imaging agents.