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Abstract #3936

Simultaneous Imaging of 13C Metabolism and 1H Structure for Improved Co-Registration and Off-Resonance Correction

Jeremy W. Gordon1, David J. Niles1, Kevin M. Johnson1, Matthew Smith1, Krishna N. Kurpad1, Eric Peterson1, Sean B. Fain1, 2

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States

Proton data can be used to aid in the reconstruction of hyperpolarized 13C metabolites, but motion between scans diminishes reconstruction fidelity. This works seeks to improve 13C reconstruction by utilizing simultaneously acquired 1H data, which are inherently registered both spatially and temporally. A simultaneous acquisition scheme was implemented in spiral and Cartesian sequences to demonstrate the feasibility and utility of concurrently acquired 1H data. Metabolite images show excellent registration with the underlying anatomy, while phase related artifacts were mitigated when 13C data was reconstructed with simultaneously acquired field maps, as compared to a field map acquired prior to simultaneous imaging.