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Abstract #3935

Hyperpolarized [1,4-13C]-Diethylsuccinate: A Potential DNP Substrate for in vivo Metabolic Imaging

Kelvin Billingsley1, Sonal Josan1, 2, Jae Mo Park1, 3, Sui Seng Tee1, Yi-Fen Yen1, Ralph Hurd4, Dirk Mayer1, 2, Daniel Spielman1, 5

1Department of Radiology, Stanford University, Stanford, CA, United States; 2Neuroscience Program, SRI International, Menlo Park, CA, United States; 3Department of Electrical Engineering, Stanford University, Stanford , CA, United States; 4Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Department of Electrical Engineering, Stanford University, Stanford, CA, United States


This work explores the synthesis, development and application of [1,4-13C]-diethylsuccinate ([13C]-DES) via DNP polarization. These studies provide a reassignment of the metabolites observed in previous reports and a reexamination of the role of the TCA cycle in processing [13C]-labeled diethylsuccinate probes.