Abstract #3949

A Device for Accurate and Automated Injection of Hyperpolarization Substrate with Minimal Dead Time and Arbitrary Volumes

Steven Reynolds¹, Adriana Bucur¹, Michael Port², Tooba Alizadeh³, Samira Kazan³, Gillian M. Tozer³, Martyn Paley¹

¹Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; ²Biological Services Unit, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; ³Department of Oncology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Modelling of hyperpolarized pyruvate to lactate conversion can be improved upon with consistent and reliable injections using an automated system. We have improved upon our previously designed injector by using a completely MR compatible direct drive peristaltic pump with a stepper motor and microcontroller. The new injector allows faster injections, no syringe filling, and arbitrary injection volumes. We show excellent correlation between demand and delivered volumes in the range 0.100-10.00ml and faster delivery of hyperpolarized pyruvate into a test phantom.