Abstract #3953

Continuous Flow 1.5T In-Bore Overhauser DNP for 1H and 13C Hyperpolarization: Quantification of Polarization Build-Up to Optimize the MR-Imaging Efficiency

Maxim Terekhov¹, Kathrin Gerz¹, Jan Krummenacker², Vasyl Denysenkov², Thomas Prisner², Laura Maria Schreiber¹

¹Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany; ²Institute of Physical and Theoretical Chemistry, Center for Bimolecular Magnetic Resonance, Goethe-University Frankfurt-am-Main, Frankfurt-am-Main, Germany

Dynamic Nuclear Polarization is a technique to achieve the polarization of MRI agents over that at thermal equilibrium by microwave irradiation of electron spins. The liquid-state Overhauser DNP (ODNP) allows placing the polarizer core inside MRI magnet close to the imaging objects and delivery of hyperpolarized agent in continuous flow mode . The net efficiency of ODNP-polarizer is a complicated trade-off for which, to our knowledge, no theoretical model exists. We performed the study to establish a method of ODNP-magnetization build-up quantification in order to optimize the SNR of the MR-images obtained with hyperpolarization of 1H and 13C nuclei.