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Abstract #3955

Diffusion Tensor Spectroscopic Imaging of Multiple Metabolites in Rat Brains

Yoshitaka Bito1, Yuko Kawai2, Koji Hirata1, Toshihiko Ebisu3, Yosuke Otake1, Satoshi Hirata1, Toru Shirai1, Yoshihisa Soutome1, Hisaaki Ochi1, Masahiro Umeda2, Toshihiro Higuchi4, Chuzo Tanaka4

1Central Research Laboratory, Hitachi, Ltd., Kokubunji-shi, Tokyo, Japan; 2Medical Informatics, Meiji University of Integrative Medicine, Nantan-shi, Kyoto, Japan; 3Neurosurgery, Nantan General Hospital, Nantan-shi, Kyoto, Japan; 4Neurosurgery, Meiji University of Integrative Medicine, Nantan-shi, Kyoto, Japan

Diffusion tensor spectroscopic imaging (DTSI), using diffusion-weighted echo-planar spectroscopic imaging with a pair of bipolar diffusion gradients (DW-EPSI with BPGs), was applied to measure diffusion tensor images (DTIs) of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) in normal rat brains. The DTIs of NAA and Cr were successfully measured, however, the DTI of Cho was deteriorated by gradually decreasing the signal of Cho. The measured DTIs of NAA and Cr are very similar to the DTI of water in most brain regions but show differences in the detail, i.e., cortex and corpus callosum. These results suggest that this DTSI technique is effective in investigating microstructures of tissue.