Abstract #3959

Nonuniformly Under-Sampled (NUS) Echo Planar J-Resolved Spectroscopic Imaging (EP-JRESI) of Prostate Cancer Patients and Compressed Sensing Reconstruction

Rajakumar Nagarajan¹, Daniel J.A. Margolis¹, Stevan S. Raman¹, Nidhi Jain¹, Robert E. Reiter², M. Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; ²Urology, University of California Los Angeles, LOS ANGELES, CA, United States

Due to its prevalence in the male population as well as its unpredictable clinical course, early detection and diagnosis of prostate cancer have become a priority for many health care professionals. The one-dimensional (1D) MRS combined with two-dimensional (2D) or three-dimensional (3D) spatial encoding is popularly known as MR Spectroscopic Imaging (MRSI) and a drawback of 1D MRS is the overlap of metabolite signals due to the limited spectral dispersion. The inherent acceleration in the echo-planar spectroscopic imaging (EPSI) can be further accelerated using non-uniform undersampling (NUS) imposed on incremented spatial and spectral dimensions of the 4D EP-JRESI sequence. The CS-reconstructed data using the split-Bregman non-linear reconstruction algorithm showed an excellent reproduction of multiple 2D J-resolved spectra with the 2D diagonal and cross peaks at the expected locations. The 25% undersampled CS-reconstructed EP-JRESI data using the endorectal receive coil showed excellent 2D J-resolved spectral quality demonstrating the clinically acceptable time (6-12 minutes) with 1ml voxel resolution.