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Abstract #3983

Quantification and Reproducibility of L-COSY in Human Brain at 7T

Gaurav Verma1, Hari Hariharan2, Rajakumar Nagarajan3, Manoj K. Sarma3, Ravi Prakash Reddy Nanga2, Edward James Delikatny2, M. Albert Thomas3, Harish Poptani1

1Department of Radiology and Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States

Localized correlated spectroscopy (L-COSY) was developed for use in 7T whole-body scanners. L-COSY was tested for reproducibility in the occipital lobe of six healthy volunteers, and tested for versatility by scanning differing anatomy including basal ganglia, frontal lobe, dorso-lateral prefrontal cortex and parieto-occipital region in two volunteers. 2D spectra showed distinct resonances of gamma-aminobutyric acid, glutathione, lysine, isoleucine, choline group and other metabolites with voxels as small as 15.6ml. After quantification with prior-knowledge based peak fitting, coefficients of variation of metabolite ratios were found comparable to existing L-COSY studies at lower field strengths.