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Abstract #3991

in-vivo Detection of GABA Using Short-TE MRS at 3 Tesla

Jamie Near1, Phil Cowen2, Peter Jezzard3

1Centre d'Imagerie Crbrale, Douglas Institute, McGill University, Montreal, Quebec, Canada; 2Department of Psychiatry, University of Oxford, Oxford, OXON, United Kingdom; 3FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom

In this study, we investigate the reproducibility of short-TE MRS measurements of GABA in the human brain at 3 Tesla. These investigations are performed through a) comparison of short-TE GABA measurements with gold-standard edited GABA measurements in the same voxel in-vivo, and b) assessment of within-session reproducibility of short-TE GABA measurements. Across 14 subjects, a significant positive relationship was observed between short-TE and edited GABA measurements (R=0.58, p<0.05), and the average coefficient of variation of multiple within-session short-TE GABA measurements was 8.7 4.9%. These results suggest that short-TE MRS may provide a reliable option for quantitative detection of GABA at 3T.