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Abstract #3992

The Influence of Chemical Shift Displacement on 1H MRS Quantitation at 3T Using a Simulated Basis Set

Martin Wilson1, 2, Theodoros N. Arvanitis, 23, Andrew C. Peet1, 2

1School of Cancer Sciences, Birmingham, West Midlands, United Kingdom; 2Birmingham Children's Hospital, Birmingham, West Midlands, United Kingdom; 3School of Electronic, Electrical & Computer Engineering, University of Birmingham, Birmingham, West Midlands, United Kingdom

In this study the effects of chemical shift displacement (CSD) on simulated basis set analyses are demonstrated for short-echo 3T MRS data collected from phantoms and patients. An improvement in fit quality was observed on metabolite phantom data when CSD effects are modelled in basis set simulation. A bias in lactate and lipid measurements was also apparent in brain tumour MRS data when CSD effects are omitted. In conclusion, CSD modelling is an important consideration for the measurement of coupled metabolites at 3T using simulated basis sets.