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Abstract #4007

Whole Body Radiation Exposure Induced Neuometabolic Alteration in Murine Brain: An in-vivo Approach of 1H and 31P MR Spectroscopy

Ahmad Raza Khan1, Poonam Rana1, Hemanth BS Kumar1, Shilpi Modi1, Saleem Javed2, Subash Khushu1

1NMR Research Centre, Institute of nuclear medicine and allied sciences, Delhi, India; 2Department of Biochemistry, Jamia hamdard, New Delhi, Delhi, India

Past few decades greater exploitation of nuclear material leads to intentional and unintentional radiation exposure cause bad impact on human health. Present study was performed to ascertain neurometabolic alteration in normal appearing brain after whole body radiation exposure. The study utilizes whole body exposure of 3 and 5 Gy radiation dose on mice and neurometabolites level were quantified in brain with 1H/31P MR Spectroscopy. The study reveals significant decrease in NAA level of hippocampus of the brain at day 30 post irradiation in both the groups while disturbed brain energy metabolism was observed in 5 Gy dose group only.