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Abstract #4017

Effect of J-Coupling on Lipid Composition Determination in vivo Using Proton MRS

Atiyah Yahya1, 2

1Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada; 2Department of Oncology, University of Alberta, Edmonton, Alberta, Canada

Lipid measurements by proton MRS are relevant to the study of a number of diseases. Most lipid protons exhibit scalar coupling interactions complicating their response to in-vivo MRS pulse sequences such as PRESS. The presented educational abstract describes J-coupling effects on the quantification of lipid peaks and consequently on lipid composition determination. In addition, methods that have been employed to compensate for these effects are described in addition to their limitations.