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Abstract #4023

Tungsten Alloy Based Heavy Metals in Ammunition and Armament May Cause Metabolic Disturbances: A Urinary Metabolomic Approach

Ritu Tyagi1, Poonam Rana1, Mamta Gupta1, Ahmad Raza Khan1, Deepak Bhatnagar2, Rajendra P. Tripathi1, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi, India; 2School of Biochemistry, Devi Ahilya University, Indore, Madhya Pradesh, India

HMTAs are composed of a mixture of tungsten (9193%), nickel (35%) and either cobalt (24%) or iron (24%) particles which are increasingly adopted as the raw material to make parts of military products. 1H NMR spectroscopy based study has been conducted for identification of metabolite markers for tungsten alloy based heavy metals toxicity. Urine sample were collected at 8, 24, 72 and 120 h p.d. of low and high dose of tungsten alloy based heavy metals. Spectral Analysis exhibits impairment of energy metabolism which is suggestive of metabolic disturbances caused by tungsten alloy based heavy metals.