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Abstract #4028

Fast & Localized 31P Saturation Transfer at 7T Reveals Slower Hepatic Metabolic Rates in NASH Patients

Ladislav Valkovic1, 2, Martin Gajdosik1, Stefan Traussnigg3, Marek Chmelk1, Ivan Frollo2, Michael Trauner3, Siegfried Trattnig1, Martin Krssk1, 3

1MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Vienna, Austria; 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia; 3Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

The goal of this study was to test the feasibility of magnetization transfer (MT) for non-invasive distinction of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). 31P-MRS MT measurements of ten suspected NAFLD/NASH and of four healthy subjects were performed on 7T system using surface coil (1H/31P). The NASH patients had significantly lower forward rate constants as compared to NAFLD patients and healthy volunteers.