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Abstract #4037

Sex-Linked Difference of Metabolic Concentrations in Hippocampus in Sprague-Dawley Rats: A High Resolution in Vivo Proton MRS Study at 7 Tesla

Su Xu1, 2, Andrew D. Marshall1, 2, Nicholas Hilker1, 2, Rao P. Gullapalli1, 2

1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; 2Core for Translational Research in Imaging @ Maryland, Baltimore, MD, United States

Although significant in vivo imaging research relies on the rodent model, very little has been reported on the gender based differences in neurometabolites among healthy rodents. The purpose of this study was to compare the metabolic concentrations obtained from normal age-matched Sprague-Dawley (SD) male, virgin female, and post-weaning female SD rats in hippocampus. We demonstrated a sex-linked difference of metabolic taurine concentration. The finding in our present study emphases the importance of sex-matching for studies investigating differences in neurometabolic concentrations.