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Abstract #4080

Intravoxel Incoherent Motion Diffusion-Weighted Imaging in Liver Fibrosis of Rat with Bile Duct Ligation

Bin Yang1, Li Wang1, Chunmei Xia2, Lixia Yang3, Zhongwei Qiao1, Ed X. Wu4

1Department of Radiology, Children Hospital of Fudan University, Shanghai, China; 2Department of Physiology and Pathophysiology, Fudan University, Shanghai, China; 3Department of Radiology, Xuhui Center Hospital, Shanghai, China; 4Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

This study aims to investigate the alteration of D, D* and perfusion faction (f) in the rat liver fibrosis with biliary duct ligation by using IVIM DW-MRI. We observed a decreasing trend of D, f and ADC of the livers from D0 to D3, D7. And the differences in D, f and ADC approached statistical significance on D7 compared to D0. There was no difference in D* of the livers from D0 to D3, D7. The reduction of true diffusion and perfusion faction would be attributed to alteration of hepatic microcirculation, portal inflammation at the early stage of liver fibrosis.