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Abstract #4081

Intravoxel Incoherent Motion MR Imaging Showed Lower Pure Molecular Diffusion in Fibrotic Livers: A Report of Preliminary Results

Pu-Xuan Lu1, Hua Huang1, Jing Yuan2, Feng Zhao2, Yi-Xiang Wang2

1Department of Radiology, the Shenzhen Third People's Hospital, Shenzhen, Guangdong, China; 2Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

11 healthy volunteers and 11 patients with liver fibrosis received IVIM DWI at 1.5-T with a single-shot EPI, with 10 b values ranging from 10 to 800 sec/mm2. Avoiding artifacts and blood vessels, an ROI was placed over the whole liver. Parameters of true diffusion coefficient D, pseudo diffusion coefficient that reflects capillary perfusion D*, and perfusion fraction f were computed by fitting the averaged intensities in the ROI with b. The D value in patients was significantly lower than that in healthy subjects (p=0.013). f value was also lower in the patients, though statistical significance was not reached (p=0.066).