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Abstract #4083

Quantitative Self-Gated Free Breathing 4D DCE MRI of the Liver with Retrospectively Selectable Temporal Resolution

Gregory R. Lee1, 2, Yong Chen3, 4, Nicole Seiberlich5, Mark A. Griswold3, 4, Vikas Gulani, 46

1Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; 2Radiology, University of Cincinnati, Cincinnati, OH, United States; 3Radiology, Case Western Reserve University, Cleveland, OH, United States; 4Radiology, University Hospitals of Cleveland, Cleveland, OH, United States; 5Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 6Radiology, University Hospitals Case Medical Center, Cleveland, OH, United States

Dynamic contrast enhanced (DCE) liver exams are typically performed using 15-20 second breath-holds at a few timepoints surrounding contrast arrival. In the present work, a multi-echo 3D radial acquisitions with nearly isotropic sample spacing regardless of timescale was employed to enable reconstruction of DCE images at multiple timescales which can be chosen retrospectively. At longer timescales, higher signal to noise ratio is available for better single volume radiologist interpretation, while at shorter timescales the dynamic contrast uptake curves can be fit to a quantitative perfusion model.